Dosimetry of short-ranged radionuclides

Journal: Nuklearmedizin Supplement 2010
ISSN: 0029–5566
Topic:

Strahlenbiologie

Issue: 2010: Nuklearmedizin Supplement 2010
Pages: 46-49

Dosimetry of short-ranged radionuclides

M. Lassmann (1)

(1) Klinik und Poliklinik für Nuklearmedizin, Universität Würzburg

Keywords

SPECT, PET, dosimetry, Bremsstrahlung

Summary

More and more targeted radiotherapies (TRT) are carried out with pure beta-emitters such as 90Y. Normally fixed activities are administered without considering the individual biokinetics increasing the risk of under- or overdosing. In addition, it would be helpful to obtain additional data on dose-response relationships for further optimization of TRTs. Therefore, post-therapeutic dosimetry using quantitative imaging becomes more important. For an optimization of TRTs additional aspects such as the changing dose rate and radiobiological considerations need to be taken into account. This paper provides an overview on bremsstrahlung imaging modalities after therapies with pure beta-emitters. In addition, new dosimetric methods are described which consider dose rate and fractionation of treatment.

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